F.A.Q.

When we are born – and our skin is soft, smooth, plump, and healthy – we have copious amounts of EGF (Epidermal Growth Factor) proteins that signal cells in relation to repair and rejuvenation. They are vital for maintaining healthy skin functions like the production of collagen, elastin, and hyaluronic acid that help keep skin thick, dense, smooth, and firm. By the time we are in our 20's, the natural production of EGF is already starting to decrease. This decrease significantly contributes to slower cell turnover and repair, eventually affecting our skin's appearance – skin starts to sag, and fine lines and wrinkles appear.

From birth until adulthood, our body produces copious amounts of growth factor proteins that are the “messengers” for our cells. There are many different types of growth factors that can be naturally found at the surface level of our skin (the epidermal layer) through to the deeper dermis layer. EGF is one of the most important growth factor proteins for healthy and youthful looking skin, helping support the production of collagen, elastin, and hyaluronic acid to keep skin looking smooth, thick, and dense.

By the time we are in our 20's, the natural production of EGF in our skin is already starting to decrease. As a result, cell turnover and repair slow, eventually affecting our skin's appearance. Skin starts to sag, becomes thinner and drier, and fine lines and wrinkles appear.

Using EGF in skincare is a way of helping target the visible aging effects resulting from the loss of EGF naturally found in our skin. This has been our goal from the beginning, and after over a decade of research, BIOEFFECT scientists invented a way to produce a plant-based EGF. Our Barley EGF is a sustainable, renewable ingredient produced in our ecologically-engineered greenhouse in Iceland, powered by geothermal energy.

EGF (Epidermal Growth Factor) is a signaling protein naturally found in skin that helps maintain healthy skin functions, including the production of collagen, elastin, and hyaluronic acid, which affect skin thickness, density, smoothness, and firmness. However, scientists have found that the natural levels of EGF in the skin diminish as we age, inevitably affecting skin's appearance.

This is why our scientists spent over a decade researching a way to develop a plant-based EGF – to help target the effects from the loss of EGF naturally found in our skin.

The results of over 50 in-house efficacy studies, conducted by our science team, have shown that topical application of our Barley EGF has a positive effect on skin's appearance. These include enhanced hydration, a more even skin tone, and visible smoothing and firming, while helping support the skin's natural production of collagen.

BIOEFFECT growth factors are unlike most other manufactured growth factors as they are purely plant-based. The majority of EGF available in the world is produced via bacteria (often E. Coli), yeast, or human/animal cells. In that process a certain biproduct, endotoxin, is synthesized. Endotoxins can have harmful effects on the human body and cause irritative skin reactions as well as inhibit the skin's natural healing process, as well as having harmful effects on the human body.

BIOEFFECT EGF is unlike most other commercial growth factors as it is purely plant-based. Resulting from over a decade of research, BIOEFFECT scientists invented a way to produce a plant-based EGF in barley plants for an unparalleled level of purity, stability, sustainability, and efficacy. As BIOEFFECT Barley EGF is produced in a plant it is therefore free of harmful biproducts and remains pure, clean, and effective – making it the perfect choice for clean and healthy skincare.

No. There is a clear difference: Growth factors are messenger proteins generally produced and used locally by the cells/tissue for repair and rejuvenation. Human growth hormones are produced by the pituitary gland for linear growth (how tall we are) and impact muscle mass and body fat.

No. BIOEFFECT's Barley EGF and other Barley growth factors are non-GMO. We manufacture the growth factors in bioengineered barley plants, grown in Iceland inside our high-tech ecologically-engineered greenhouse powered by geothermal energy. The resulting products, Barley EGF and other Barley Growth Factors, while derived using biotechnology, are not GMO.

Yes, BIOEFFECT products are safe and suitable for all skin types – even sensitive. We strive to use as few and as pure ingredients as possible and only those that our skin can truly understand. Our skincare products are nontoxic and free from fragrance, paraben, phthalate, alcohol*, and mineral-oil.

We recommend that people who have, or have had, a medical history of skin diseases, disorders, or are prone to allergies, to consult their health professional before using a new skin care product.

*EGF Power Cream contains cetyl alcohol, a hybrid of alcohols and fatty acids that functions as an emollient.

Yes. However, if you do plan to incorporate other (non-BIOEFFECT) skincare into your routine, we recommend applying BIOEFFECT EGF and growth factor products first and waiting a few minutes to let them absorb before applying other products – including makeup. The reason is that many popular cosmetics ingredients have been shown to change the structure of growth factor proteins and decrease their efficacy when in contact with them. Therefore, we encourage you to let your Barley growth factor skincare product absorb in an uncompromised environment for the growth factors to become fully effective.

We do recommend you adopt a daily Barley growth factor skincare routine for the best results. Our studies show that the benefits are more powerful when layering multiple BIOEFFECT products, as they are specifically developed to complement each other.

Most of our products are oil-free with the exception of the Volcanic Exfoliator and EGF Power Cream. The reason most our products are oil-free is the fact that several ingredients, including some oils and alcohols, can diminish the performance of our Barley EGF and other Barley growth factors. These are unique proteins that require precise formulation of compatible ingredients to ensure maximum efficacy and best results.

The Volcanic Exfoliator contains Sunflower oil – rich in linoleic acid, an essential fatty acid shown to help maintain skin’s natural moisture barrier and prevent transepidermal water loss (TEWL).

The EGF Power Cream contains Shea butter and Evening Primrose oil – moisturizing and nourishing ingredients that are also a source of replenishing fatty acids. Ideal for mature or dry skin in need of extra hydration.

No, the Hydrating Cream is oil-free and does not contain Coconut Oil. We have heard some users ask if caprylic/capric triglyceride is basically a form of coconut oil. They have also wondered if it is a vegetable oil since it is a triglyceride. We have assured these users it is not. We have carefully selected all ingredients in the Hydrating Cream for their synergic benefits without the negatives associated with mineral or vegetable oils. It is made differently than vegetable oils. Caprylic/capric triglyceride is a highly purified emollient and lubricant designed for oil-free moisturizers to improve application whilst helping to replenish skin leaving it soft with a non-greasy feel. We selected caprylic/capric triglyceride because it works well with our Barley growth factors.

Our plant-based EGF and other Barley growth factors are produced in barley plants in our ecologically engineered greenhouse in Iceland. However, we do not use certified organic ingredients and therefore, cannot claim that our finished skincare products are certified “organic”.

Yes. According to EU standards, a product can be called “gluten-free” if the gluten content is below 20 parts per million (ppm). At BIOEFFECT, we conducted testing on all our products using the most sensitive method available, the ELISA (enzyme-linked immunosorbent assay) protocol. With these sensitive techniques, the gluten concentration in all BIOEFFECT products measures between 5,000 – 50,000 times below the EU standards for claiming Gluten Free. In fact, our EGF Serum is 13,000 times below this standard. In 2013 the US FDA concurred with these standards.

BIOEFFECT products do not contain any of the ingredients found on lists of skincare substances recommended to be avoided during pregnancy. In addition, all ingredients of BIOEFFECT products are legally permitted as cosmetic ingredients as per EU Directives 76/768/EEC. However, no specific studies have been carried out on using BIOEFFECT products during pregnancy. We recommend pregnant women to consult with their physician before using BIOEFFECT products, as they would with any other active skincare product.

All BIOEFFECT products have a shelf life of 2 years and an expiration date is printed on the bottom of the boxes along with the lot number.

Most of the main components of our primary packaging and all our secondary packaging are recyclable. Our number one priority is always the safety and effectiveness of the formulations. We continue to investigate innovative sustainable packaging materials and strive to improve as new technologies emerge.

BIOEFFECT skincare products are plant-based and do not use any animal ingredients or animal-derived ingredients.

No, BIOEFFECT does not test its products or ingredients on animals, nor do we arrange for others to do so on our behalf. We have always been committed to animal welfare and are in complete compliance with the EU regulations in that regard. However, animal tests may be required by regulations in certain regions, e.g. China, where authorities could conduct their own tests on imported beauty and skincare products.

BIOEFFECT has a Quality Management System (QMS) in place to meet expectations of all stakeholders (consumers, owners, employees, and authorities) and it is certified by an approved certification body. This implies that all aspects of our operations are taken into consideration to maintain an acceptable quality level which supports and builds the brand’s premium image. Meeting our quality objectives requires focus and commitment from company staff, as well as management, suppliers, contractors, distributors, and retailers.

The Quality Management System is based on three documents:

• ISO-9001:2015 Quality Management System – Requirements
• ISO 22716:2007 Cosmetics - Good Manufacturing Practices (GMP) – Guidelines
• REGULATION (EC) No 1223/2009 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 30 November 2009 on cosmetic products

Glycerin has many and complex effects on the skin, both direct and indirect. To name a few, glycerin works as a protective agent against skin irritation, it has an antimicrobial effect on the skin, it can enhance the penetration of other active ingredients into the skin, it aids in the wound healing process, and also increases hydration/moisturization of the skin. To be able to get the maximal benefit from glycerin, the composition of the formulation of the product is critical. Therefore, BIOEFFECT products have the optimum concentration of water in the formulation for glycerin to have a very effective hydrating function. If glycerin is applied undiluted on the skin, it can result in dehydration due to osmotic water extraction from the top layers of the skin.

BIOEFFECT EGF Serum is an award-winning, oil-free, water-based, anti-aging serum that contains only 7 pure ingredients. It was specifically developed to target visible signs of skin aging. It is the first serum to feature a plant-based EGF, namely our Barley EGF which is a moisture-binding and skin-rejuvenating signaling protein that helps support the skin’s natural collagen production and is essential for keeping skin looking smooth, healthy, and youthful.

BIOEFFECT EGF Serum is designed to target visible signs of aging and rejuvenate the skin’s complexion with just 2-4 drops daily. External and in-house studies show a reduction in the appearance of wrinkles, boosted skin moisture levels, and visible improvements in skin elasticity and firmness.

Apply 2-4 drops to the face, neck, and décolleté. Can be used morning and night. Apply in the morning and let absorb before applying a moisturizer, sunscreen, or makeup. Apply in the evening to clean skin for advanced skin repair while you sleep.

Can be used alone or with other BIOEFFECT products for maximum benefit, as Barley EGF does its best work in a moisture-rich environment. We recommend layering on top of the EGF Essence and then follow with a face cream, e.g. the Hydrating Cream or EGF Power Cream. Also try pairing with an Imprinting Hydrogel Mask to boost results even further.

If using with other skincare products (non-BIOEFFECT), we recommend applying the serum on clean skin and waiting up to 10 minutes for absorption and efficacy of the Barley EGF without any interference.

Yes. Together, the Barley EGF and hyaluronic acid hydrate the skin and aid in moisture retention while boosting moisture levels, nourishing, and helping soften the skin. BIOEFFECT EGF Serum is particularly beneficial for visibly dry and sensitive skin and numerous users have reported that their dry spots appear to diminish as the skin becomes more hydrated. Our efficacy studies have reported a significant increase in skin hydration when using the EGF Serum.

BIOEFFECT EGF Serum features a plant-based EGF produced in Barley. The topical application of Barley EGF is a way to help target the visible effects resulting from the loss of EGF found naturally in our skin.

By the time we are in our 20's, the natural production of naturally-occurring EGF is already starting to decrease. This decrease significantly contributes to slower cell turnover and repair, eventually affecting our skin's appearance – skin starts to sag, and fine lines and wrinkles appear.

Barley EGF is a moisture-binding and skin-rejuvenating signaling protein, that helps support the skin’s natural collagen production and is essential for keeping skin looking smooth, firm, and healthy.

Studies of the EGF Serum applied topically over 3 and 6 months have shown a significant reduction in the appearance of wrinkles.

The BIOEFFECT EGF Serum is intensely moisturizing on its own. It is possible that fatty/oily substances in traditional night creams may reduce the efficacy of Barley EGF (Epidermal Growth Factor). We therefore only recommend using BIOEFFECT creams, e.g. the Hydrating Cream or the EGF Power Cream, on top of our serums, as we have carefully selected each ingredient in all our products making sure to use only those that complement each other and don't affect the structure and efficacy of the barley growth factors. Wait for a few minutes and let the serum absorb if you wish to follow your serum with a BIOEFFECT cream.

BIOEFFECT EGF Serum was specifically formulated to target the delicate skin of the face and neck. Nevertheless, it could be used on the body as well. We do recommend using the BIOEFFECT EGF Body Serum on the body, as it was specifically developed to help smooth, soften, and firm the appearance of the body's skin.

There have been no specific trials on sufferers of eczema. However, we understand eczema sufferers' skin can be easily irritated and this may be a concern when choosing skincare products. BIOEFFECT EGF Serum features only 7 pure ingredients, and is free from fragrance, oil, alcohol, paraben, and gluten. It has been shown to improve hydration and soften visibly dry skin.

No preservatives are used in the production of BIOEFFECT EGF Serum. We pride ourselves in only using those ingredients necessary to deliver the Barley EGF in its most effective form.

BIOEFFECT EGF Serum is an oil-free, water-based, anti-aging serum that contains only 7 pure ingredients – we like to say only the ingredients that matter. The signature ingredient is our Barley EGF, that helps boost hydration and support the skin’s natural collagen production, minimizing the appearance of fine lines and wrinkles. It also features Hyaluronic Acid, Barley Seed Extract, Glycerin, and Icelandic water filtered through lava, so it is pure and extremely soft, free of hard minerals that leave skin dry.

No. We strive to keep our products as pure as possible, so no fragrances are added to any of our products.

Yes, many users prefer to apply the serum on clean skin in the morning and some use it both day and night. It is advisable not to apply makeup or any other products within a few minutes of using BIOEFFECT EGF Serum, as it may interfere with the EGF's efficacy. The serum does not contain any sun protection, so we recommend using a sunscreen to protect from harmful UV rays. If you find the EGF Serum leaves more of a residue or sticky feeling than you would like during the day, try using less of the product. You could also try our EGF Day Serum which is a lighter formulation with a gel texture.

You do not need to use both the EGF Serum and EGF Day Serum – it is a matter of preference. We created the EGF Day Serum as a lighter formulation with a gel-like texture, that some find more suitable for daytime use and is ideal under makeup. However, many customers prefer the original EGF Serum and use it both morning and night. For best results, we recommend applying our serums twice per day.

Our Barley EGF works best in a moisture-rich environment. Therefore, you can maximize results by incorporating the EGF Serum into a complete Barley growth factor skincare routine. Start by prepping the skin with the EGF Essence to improve the absorption and efficacy of the EGF Serum. Further enhance results by adding a face cream, e.g. the Hydrating Cream or the EGF Power Cream. You can also maximize the efficacy of Barley EGF by using an Imprinting Hydrogel Mask after applying the EGF Serum. Compliment with the EGF Eye Serum to specifically target the delicate eye contour.

The skin in the largest organ of the body, which is why we believe it deserves a boost every now and then. Replace the EGF Serum with the 30 Day Treatment – our most potent product – 1-4 times year to supercharge your regular skincare. Provides you with a concentrated skin boost in just 30 days!

Growth factors are rare and expensive ingredients. BIOEFFECT Barley growth factors are the result of yearlong development and knowledge along with the use of premium devices, techniques, and systems. The complex and costly manufacturing process ensures the highest possible quality of our product. The outstanding operational methods and the plant-based foundation are what make our growth factors uniquely safe, clean, and stable. Although the bottle may be small, the serum inside is incredibly potent and spreads well, so you don’t need as much. If the serum is applied on the face and neck once a day, 2-4 drops each time, the 15 ml bottle should last up to three months.

The EGF Power Serum formula is more potent than the EGF Serum as it has a higher concentration of EGF.

EGF Power Serum is ideal for those already seeing visible signs of skin aging, including fine lines, wrinkles, loss of density, and uneven skin tone, whereas the EGF Serum is very well suited to maintain skin condition or prevent visible signs of aging in skin. Those wanting a more intensely age-defying product may therefore look to the EGF Power Serum.

The EGF Power Serum formula contains 2 growth factors (EGF and KGF) along with NAG for treating hyperpigmentation in the skin. The EGF Serum formula contains 1 barley growth factor, the EGF.

It is suitable for all skin types but ideal for dry and mature skin and those looking to intensely target visible signs of skin aging.

Both products deliver intensely age-defying benefits to the skin.

The EGF Power Serum can be used twice daily, throughout the year. The 30 Day Treatment is intended to be used for 30 consecutive days, as a boost to your regular skincare routine.

We recommend using the 30 Day Treatment when your skin needs a restorative boost, and then maintaining the results with the EGF Power Serum, ideal for your everyday skincare.

The EGF Power Serum formula contains 2 growth factors (EGF and KGF) compared to 3 growth factors (EGF, KGF, and IL-1a) in the 30 Day Treatment, making it our most potent product.

The clear, silky, and smooth texture allows the serum to absorb quickly into the skin without leaving a sticky residue. It is free from fragrance, parabens, silicone, gluten, and alcohol.

Yes, preferably day and night for maximum results.

We recommend using one serum at a time depending on age and skin concern. For added hydration and nourishment, we recommend using an occlusive moisturizer (EGF Power Cream or Hydrating Cream) on top of the serum if needed. The EGF Power Serum formulation is based on the EGF Serum, but more potent and targeted towards more mature skin, ideal for those looking to intensely target visible signs of skin aging.

Yes, the two products can be used together for added nourishing benefits and a more intense age-defying routine if needed (depending on skin type, season, etc.). The “Power” products are specifically developed for those already seeing visible signs of skin aging, including fine lines, wrinkles, and hyperpigmentation. They work wonders on their own but are also suited to be used together as a Power skincare regimen. Therefore, we recommend starting with the EGF Power Serum and then layering the EGF Power Cream on top to securely lock in the moisture for maximum benefit.

Both Barley Beta Glucan, found in EGF Power Cream, and Barley KGF, found in EGF Power Serum, affect the skin barrier. Barley Beta Glucan aids in the skin barrier’s ability to seal in moisture whereas KGF helps keep it intact and healthy-looking. When used together, the EGF Power Serum and EGF Power Cream intensely affect the skin barrier by strengthening it and enhancing its ability to seal in moisture for added hydration to the skin.

By pairing NAG, found in the EGF Power Serum, with Niacinamide, found in the EGF Power Cream, you also visibly enhance overall complexion by targeting hyperpigmentation, evening skin tone, and increasing radiance.

EGF and KGF are growth factors known to assist in the skin repairing process. In addition to containing Barley EGF and Barley KGF, the EGF Power Serum formula is hypoallergenic and non-irritant. Therefore, the EGF Power Serum can be used after laser or peeling treatments. However, we would always recommend you consult with your dermatologist in advance.

KGF is known to promote and strengthen the skin barrier and make it more structured, by stimulating keratinocytes in the epidermis to affect production of Hyaluronic Acid. It has also been shown that KGF has oxidative properties and protects skin against UV-radiation.

NAG is a precursor to Hyaluronic Acid, so it is one of the building blocks of Hyaluronic Acid together with D-Glucuronic Acid – an active naturally found in the skin.

NAG (N-Acetyl Glucosamine) reduces production of melanin in the skin, thereby improving hyperpigmentation and skin tone.

All BIOEFFECT.com orders receive complimentary USPS Priority Shipping (minimum $40 order). For all international addresses BIOEFFECT.com ships with DHL Ecommerce for a standard charge of $25.00. Please note, international shipments will be subject to import taxes, duties and customs fees, and are the responsibility of the recipient.

BIOEFFECT.com processes orders Monday-Friday (except during holidays) in the order in which they are received. Please allow 3-5 business days for the processing and shipping of all orders. USPS delivers Monday-Friday.

At this time, Bioeffect.com does not ship to APO/FPO, PO Boxes and U.S. Territories.

Internationally we ship to all countries except for: Canada, United Kingdom, Austria, Belgium, Bulgaria, China, Costa Rica, Denmark, Finland, France, Germany, Hong Kong, Iceland, Ireland, Japan, Kenya, Luxembourg, Macao, Mexico, Netherlands, Panama, Russia, Saudi Arabia, South Korea, South Sudan, Sweden, Switzerland, Thailand, United Arab Emirates, French Southern Territories, Heard Island And Mcdonald Islands, Korea, Democratic People’s Republic of North Korea, South Georgia And The South Sandwich Islands.

After your order has shipped, you will receive a Shipping Confirmation email with tracking information so that you may check status of the order at your convenience.

Once your order has shipped, you will receive a Shipping Confirmation email with a tracking number for your order. Please allow approximately 3-5 days for the processing and shipping of all orders. If you have questions about shipping or tracking your order, we can assist you if you contact us via email [email protected], we usually answer all the mails within 24hours.

Please feel free to contact us directly by email [email protected]

BIOEFFECT’s Auto-Delivery program is the most convenient way to receive your favorite BIOEFFECT products exactly when you want them delivered. The products are automatically sent based upon your chosen shipment frequency, so you never run out.

Signing-up is easy! From the product page, simply select the Auto-Delivery option for your desired product, select your preferred shipment frequency and then check out as normal.

Please note that in order to subscribe to Auto-Delivery you will need a BIOEFFECT.com account.

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You will only be billed on the day the order is shipped. We will send an email reminder 3 days before each auto-delivery order. You will also receive email notifications regarding other important information related to your auto-delivery account, such as if your item is discontinued or out of stock, if you cancel your replenishment, and/or confirmation when an order is placed successfully.

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Auto-delivery orders will only contain sample on first order and all recurring orders will not contain samples.

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Simply shop online and add items to your shopping bag and checkout as normal. At the checkout choose Installments with Afterpay as your payment method. First-time customers will need to register with Afterpay and provide payment details, as usual, returning customers simply log in to make their purchase. It’s that easy!

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